IVIG treatment for repeated hypothermic attacks associated with LGI1 antibody encephalitis
نویسندگان
چکیده
Hypothermia, defined as a core body temperature of ,35.0°C (,95.0°F), is a life-threatening and emergency situation. Various conditions and diseases can cause hypothermia, including environmental exposure, drug intoxication, CNS diseases, and metabolic abnormalities, such as hypopituitarism, hypoadrenalism, hypothyroidism, and hypoglycemia. Leucine-rich glioma-inactivated 1 (LGI1) antibody– associated encephalitis is an autoimmune-mediated encephalitis in which autoantibodies are directed against a voltage-gated potassium channel (VGKC) complex protein named LGI1. The LGI1 protein is widely expressed in the neurons of the CNS and also in the hypothalamus. Central hypothermia associated with autoimmune-mediated encephalitis is rare; however, it is a potentially life-threatening symptom of encephalitis. Here, we describe a patient who experienced repeated hypothermic attacks associated with anti–LGI1 encephalitis.
منابع مشابه
O18: Autoimmune Encephalitis (Pathophysiology, Clinical Signs and Diagnos Tic Tests)
Autoimmune encephalitis is a difficult clinical diagnosis due to the similarities in the clini­cal, imaging and laboratory findings of many forms of autoimmune and infectious encephalitis. Autoimmune encephalitis involves several types: The first group includes the classic paraneo­plastic disorders associated with antibodies to intracellular antigens. The second group involves autoanti...
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